Here’s an interesting question. does drug treatment in pregnancy affect the bone density of offspring The answer next. Medication use and rheumatoid disease activity. the possible effect on offspring. Prednisone use and active disease are associated with reduced bone density in patients with rheumatoid arthritis. The question then is this. do these factors also affect the bone density of children born to mothers with either of these issues A Dutch study from the Erasmus Medical Center in Rotterdam published in Arthritis and Rheumatology followed 255 mothers and 108 children of these mothers. What the investigators.